Rodrigo Isgró is back in the Harlequin F.C. starting lineup, and the London club is hoping his return can help spark a turnaround.

Harlequins welcomes RC Vannes to Twickenham Stoop on Sunday, Oct. 18, for its 2026-27 EPCR Challenge Cup opener. Head coach Jason Gilmore has made four changes following a narrow defeat to Sale Sharks, with Isgró returning on the wing alongside captain Cadan Murley and fullback George Furbank.

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Marcus Smith starts at fly-half for Harlequins, with Guido Petti joining the back row and young hooker Jimmy Staples in line for his European debut from the bench. Vannes counters with Simione Kuruvoli at scrum-half, Jean Cotarmanac'h at fly-half and Rudi Brown anchoring the back row.

Here are the confirmed lineups, kickoff details and how to watch.

Harlequins vs. Vannes Kickoff Time

• Date: Sunday, Oct. 18, 2026

• Kickoff: 8 a.m. ET

• Venue: Twickenham Stoop, London, England

• Competition: EPCR Challenge Cup, Round 1

• Pool: 3

How To Watch Harlequins vs. Vannes

Harlequins vs. RC Vannes will stream live on FloRugby and the FloSports app in the United States.

Kickoff is scheduled for 8 a.m. ET on Sunday, Oct. 18. Fans can watch live or on demand with a FloRugby subscription.

Harlequins Starting Lineup vs. RC Vannes

1. Will Hobson

2. Sam Riley

3. Simon Kerrod

4. James Dun

5. Kieran Treadwell

6. Guido Petti

7. Seb Driscoll

8. Lucas Schmid

9. Lucas Friday

10. Marcus Smith

11. Cadan Murley (c)

12. Bryn Bradley

13. Luke Northmore

14. Rodrigo Isgró

15. George Furbank

Harlequins Replacements

16. Jimmy Staples

17. Harry Johnson-Holmes

18. Ollie Streeter

19. Elliot Williams

20. Harry Browne

21. Will Evans

22. Will Porter

23. Tyrone Green

RC Vannes Starting Lineup vs. Harlequins

1. Wayan de Benedittis

2. Théo Béziat

3. Santiago Medrano

4. Thomas Ployet

5. Matteo Desjeux

6. Bautista Pedemonte

7. Steeve Blanc-Mappaz

8. Rudi Brown

9. Simione Kuruvoli

10. Jean Cotarmanac'h

11. Enzo Benmegal

12. Inia Tabuavou

13. Marin Boulier

14. Paul Bard

15. Joe Jonas

Vannes Replacements

16. Hayam El Bibouji

17. Hugo Djehi

18. Simon Bourgeois

19. Jesse Stegenhuis

20. Basile Paul

21. Mikheil Alania

22. Robin Gicquel

23. Robin Taccola

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What Rugby Competitions Can I Watch On FloRugby?

FloRugby streams competitions including the Investec Champions Cup, EPCR Challenge Cup, United Rugby Championship, Gallagher PREM Rugby and Top 14, subject to regional availability.

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